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Canopy-logo_solid_4c-3Using Spatial Proteomics to Investigate the Transition From Beneficial to Maladaptive Inflammatory Tissue in Chronic Liver Disease

Chronic liver diseases result from a range of metabolic or inflammatory dysfunctions, often associated with unhealthy lifestyle or continuous alcohol consumption. In the manifestation of chronic liver diseases, the deposition of lipid droplets in liver tissue (steatosis) contributes significantly to the proinflammatory milieu (steatohepatits) and leads to portal hypertension and fibrosis (cirrhosis). The underlying immune response as well as the resulting cell-cell interactions are still poorly understood.

In this webinar, Nico Kraus, clinical research associate at University Hospital Frankfurt, will highlight the differences between the various stages of chronic liver disease in animal models. Using the Cellscape Ultra High 17-Plex Immuno Panel on OCT murine liver tissue, Kraus and colleagues identified cell-cell interactions responsible for altering the immune response and metabolic changes in newly designed mouse models by spatio-temporal analysis.